Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Sep 16;12(18):2591-4.
doi: 10.1016/s0960-894x(02)00515-2.

DNA binding ligands with excellent antibiotic potency against drug-resistant gram-positive bacteria

Roland W Bürli  1 , Yigong Ge, Sarah White, Eldon E Baird, Sofia M Touami, Matthew Taylor, Jacob A Kaizerman, Heinz E Moser
Affiliations

DNA binding ligands with excellent antibiotic potency against drug-resistant gram-positive bacteria

Roland W Bürli et al. Bioorg Med Chem Lett. .

Abstract

An efficient synthesis of DNA binding molecules consisting of four heterocyclic carboxamide units and various substituents at both termini is described. The minor-groove binding ligands showed excellent activity against a broad range of Gram-positive bacteria; no cross-resistance to known antibacterial drugs was observed.

PubMed Disclaimer

Publication types

LinkOut - more resources