Review
. 2002 Sep;25(9):438-41; discussion 441.
doi: 10.1016/s0166-2236(02)02232-4.
Raising the speed limit--fast Ca(2+) handling in dendritic spines
Affiliations
- PMID: 12183197
- DOI: 10.1016/s0166-2236(02)02232-4
Item in Clipboard
Review
Raising the speed limit--fast Ca(2+) handling in dendritic spines
Trends Neurosci.
2002 Sep.
Abstract
Ca2+ influx into dendritic spines is involved in the induction of both long-term potentiation (LTP) and long-term depression (LTD) by activating distinct biochemical cascades, depending on the stimulation protocol. Such conditional activation can be explained by the finding that removal of Ca2+ from spines is extremely rapid (approximately 15 ms) and promoted by a low endogenous buffering capacity. As a consequence, the time course of influx and binding kinetics are important determinants of how much Ca2+ binds to a particular enzyme. In addition structural factors, such as shape and dendritic location, could contribute to fine-tuning of spine Ca2+ handling and synaptic modification.
Similar articles
-
Plasticity of calcium channels in dendritic spines.Nat Neurosci. 2003 Sep;6(9):948-55. doi: 10.1038/nn1112. Nat Neurosci. 2003. PMID: 12937422
-
The life cycle of Ca(2+) ions in dendritic spines.Neuron. 2002 Jan 31;33(3):439-52. doi: 10.1016/s0896-6273(02)00573-1. Neuron. 2002. PMID: 11832230
-
Spine Ca2+ signaling in spike-timing-dependent plasticity.J Neurosci. 2006 Oct 25;26(43):11001-13. doi: 10.1523/JNEUROSCI.1749-06.2006. J Neurosci. 2006. PMID: 17065442 Free PMC article.
-
Ca(2+) signaling in dendritic spines.Curr Opin Neurobiol. 2001 Jun;11(3):349-56. doi: 10.1016/s0959-4388(00)00218-x. Curr Opin Neurobiol. 2001. PMID: 11399434 Review.
-
Role of Drebrin in Synaptic Plasticity.Adv Exp Med Biol. 2017;1006:183-201. doi: 10.1007/978-4-431-56550-5_11. Adv Exp Med Biol. 2017. PMID: 28865021 Review.
Cited by
-
Experimental and computational aspects of signaling mechanisms of spike-timing-dependent plasticity.HFSP J. 2009 Aug;3(4):240-54. doi: 10.2976/1.3137602. Epub 2009 Jun 3. HFSP J. 2009. PMID: 20119481 Free PMC article.
-
Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling.J Neurosci. 2009 Nov 25;29(47):14687-700. doi: 10.1523/JNEUROSCI.1160-09.2009. J Neurosci. 2009. PMID: 19940164 Free PMC article.
-
Local signaling with molecular diffusion as a decoder of Ca2+ signals in synaptic plasticity.Mol Syst Biol. 2005;1:2005.0027. doi: 10.1038/msb4100035. Epub 2005 Dec 13. Mol Syst Biol. 2005. PMID: 16729062 Free PMC article.
-
The kinetic profile of intracellular calcium predicts long-term potentiation and long-term depression.J Neurosci. 2004 Nov 3;24(44):9847-61. doi: 10.1523/JNEUROSCI.0738-04.2004. J Neurosci. 2004. PMID: 15525769 Free PMC article.
-
Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection.Cell Rep. 2014 Feb 13;6(3):431-7. doi: 10.1016/j.celrep.2014.01.005. Epub 2014 Jan 30. Cell Rep. 2014. PMID: 24485660 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
