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. 2002 Sep;46(9):3088-90.
doi: 10.1128/AAC.46.9.3088-3090.2002.

Incidence of high-level evernimicin resistance in Enterococcus faecium among food animals and humans

Frank Møller Aarestrup  1 , Paul M McNicholas
Affiliations

Incidence of high-level evernimicin resistance in Enterococcus faecium among food animals and humans

Frank Møller Aarestrup et al. Antimicrob Agents Chemother. 2002 Sep.

Abstract

Six high-level evernimicin-resistant Enterococcus faecium isolates were identified among 304 avilamycin-resistant E. faecium isolates from animals and 404 stool samples from humans with diarrhea. All four animal isolates, and one of the human isolates, were able to transfer resistance to a susceptible E. faecium strain. The resulting transconjugants all tested positive for the presence of emtA, a gene encoding a methyltransferase previously linked with high-level evernimicin resistance. The four transconjugants derived from animal isolates all carried the same plasmid, while a differently sized plasmid was found in the isolate from humans. This study demonstrated a low incidence of high-level evernimicin resistance mediated by the emtA gene in different E. faecium isolates of animal and human origin.

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Figures

FIG. 1.
FIG. 1.
PFGE profile of six high-level evernimicin-resistant E. faecium isolates from humans and broilers. Lanes 1 and 8, 50-kb ladder; lane 2, isolate 1 from humans; lane 3, isolate 2 from humans; lanes 4 to 7, isolates 1 to 4, respectively, from broilers.
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