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Clinical Trial
. 2002 Sep;70(9):4946-54.
doi: 10.1128/IAI.70.9.4946-4954.2002.

Effect of vaccination with carrier protein on response to meningococcal C conjugate vaccines and value of different immunoassays as predictors of protection

Moya Burrage  1 , Andrew Robinson, Ray Borrow, Nick Andrews, Joanna Southern, Jamie Findlow, Sarah Martin, Carol Thornton, David Goldblatt, Michael Corbel, Dorothea Sesardic, Keith Cartwight, Peter Richmond, Elizabeth Miller
Affiliations
Clinical Trial

Effect of vaccination with carrier protein on response to meningococcal C conjugate vaccines and value of different immunoassays as predictors of protection

Moya Burrage et al. Infect Immun. 2002 Sep.

Abstract

In order to plan for the wide-scale introduction of meningococcal C conjugate (MCC) vaccine for United Kingdom children up to 18 years old, phase II trials were undertaken to investigate whether there was any interaction between MCC vaccines conjugated to tetanus toxoid (TT) or a derivative of diphtheria toxin (CRM(197)) and diphtheria-tetanus vaccines given for boosting at school entry or leaving. Children (n = 1,766) received a diphtheria-tetanus booster either 1 month before, 1 month after, or concurrently with one of three MCC vaccines conjugated to CRM(197) or TT. All of the MCC vaccines induced high antibody responses to the serogroup C polysaccharide that were indicative of protection. The immune response to the MCC-TT vaccine was reduced as a result of prior immunization with a tetanus-containing vaccine, but antibody levels were still well above the lower threshold for protection. Prior or simultaneous administration of a diphtheria-containing vaccine did not affect the response to MCC-CRM(197) vaccines. The immune responses to the carrier proteins were similar to those induced by a comparable dose of diphtheria or tetanus vaccine. The results also demonstrate that, for these conjugate vaccines in these age groups, both standard enzyme-linked immunosorbent assays and those that measure high-avidity antibodies to meningococcal C polysaccharide correlated equally well with assays that measure serum bactericidal antibodies, the established serological correlate of protection for MCC vaccines.

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Figures

FIG. 1.
FIG. 1.
Meningococcal serogroup C IgG GMC or rSBA GMT and 95% CIs 1 month after administration of the Baxter MCC-TT vaccine, according to timing of administration of DT or Td vaccine.
FIG. 2.
FIG. 2.
Meningococcal serogroup C IgG GMC or rSBA GMT and 95% CIs 1 month after administration of the Chiron CRM, Wyeth CRM, or Baxter-TT vaccine (group 2)
FIG. 3.
FIG. 3.
Scatter plots showing results of the three ELISAs and SBA for the 672 paired sera.
See this image and copyright information in PMC

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