Huntingtin fragments that aggregate go their separate ways
- PMID: 12191468
- DOI: 10.1016/s1097-2765(02)00609-3
Huntingtin fragments that aggregate go their separate ways
Abstract
N-terminal region of mutant huntingtin forms intranuclear and cytoplasmic aggregates in neurons that may contribute to neuronal death in Huntington's disease. show that different endoprotease-cleaved huntingtin fragments form nuclear and cytoplasmic inclusions.
Comment on
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Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions.Mol Cell. 2002 Aug;10(2):259-69. doi: 10.1016/s1097-2765(02)00602-0. Mol Cell. 2002. PMID: 12191472
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