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. 2002 Aug;50(8):1013-6.
doi: 10.1248/cpb.50.1013.

New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities

Atta-Ur-Rahman  1 , Muhammad Nadeem Akhtar, Muhammad Iqbal Choudhary, Yoshisuke Tsuda, Bilge Sener, Assad Khalid, Masood Parvez
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Free article

New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities

Atta-Ur-Rahman et al. Chem Pharm Bull (Tokyo). 2002 Aug.
Free article

Abstract

Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5alpha-cevanin-23-ene-3beta,6beta,16beta-triol] and forticine (2) [(20S,22S,25S)-5alpha-cevanine-3beta,6beta-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity.

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