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Comment
. 2002 Aug;3(2):155-6.
doi: 10.1016/s1534-5807(02)00228-9.

Numb: "Adapting" notch for endocytosis

Hamed Jafar-Nejad  1 , Koenraad Norga, Hugo Bellen
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Numb: "Adapting" notch for endocytosis

Hamed Jafar-Nejad et al. Dev Cell. 2002 Aug.
Free article

Abstract

During sensory organ precursor divisions in Drosophila, the numb gene product segregates asymmetrically into one of the two daughter cells, to which it confers a specific fate by inhibiting Notch signaling. In this issue of Developmental Cell, Berdnik et al. show that Numb recruits alpha-Adaptin and that this physical interaction plays a role in downregulating Notch, presumably by stimulating endocytosis of Notch.

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