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Review
. 2002 Sep;55(9):648-55.
doi: 10.1136/jcp.55.9.648.

Cell kinetics and cell cycle regulation in lymphomas

L Leoncini  1 , S Lazzi, C Bellan, P Tosi
Affiliations
Review

Cell kinetics and cell cycle regulation in lymphomas

L Leoncini et al. J Clin Pathol. 2002 Sep.

Abstract

The proliferative indices of non-Hodgkin's lymphomas are useful prognostic indicators and provide information independent of other histological and clinical variables. However, proliferative indices alone do not suffice to characterise cell growth. A high cell production rate may be compensated, almost or fully, by a high cell deletion rate. A re-evaluation of parameters of cell kinetics in view of our increasing knowledge of the molecular pathways of cell cycle control may provide more prognostic information for the management of patients with malignant lymphomas.

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Figures

Figure 1
Figure 1
Immunostaining for (A) cyclin A and (B) cyclin B. Cyclin A is localised in the nucleus, whereas cyclin B shows either cytoplasmic or cytoplasmic and nuclear positivity.
Figure 2
Figure 2
Schematic representation of a molecular networking model for cell cycle regulation of the G1 phase.
Figure 3
Figure 3
Schematic representation of a molecular networking model for cell cycle regulation of the G2–M phase.
See this image and copyright information in PMC

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References

    1. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the international lymphoma study group. Blood 1994;5:1361–92. - PubMed
    1. Harris NL, Jaffe ES, Diebold J, et al. The World Health Organization classification of neoplastic diseases of the haematopoietic and lymphoid tissues: report of the clinical advisory committee meeting, Airlie House, Virginia, November 1997. Histopathology 2000;36:69–86. - PubMed
    1. Weiss LM, Strickler JG, Medeiros LJ, et al. Proliferative rates of non-Hodgkin's lymphomas as assessed by Ki-67 antibody. Hum Pathol 1987;18:1155–9. - PubMed
    1. Hall PA, Levison DA, Woods AL, et al. Proliferating cell nuclear antigen (PCNA) immunolocalizaton in paraffin section: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 1990;162:285–94. - PubMed
    1. Brandt L, Johnson A, Olsson H, et al. Mitotic activity and survival in advanced non-Hodgkin's lymphoma of unfavourable histology. Eur J Cancer 1990;26:227–30. - PubMed

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