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. 2002 Sep;5(9):833-4.
doi: 10.1038/nn912.

Differential regulation of synaptic and extra-synaptic NMDA receptors

Bo Li  1 , Nansheng Chen, Tao Luo, Yo Otsu, Timothy H Murphy, Lynn A Raymond
Affiliations

Differential regulation of synaptic and extra-synaptic NMDA receptors

Bo Li et al. Nat Neurosci. 2002 Sep.

Abstract

A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown--the decline of peak current with repeated, sustained agonist application. Here we report that calcium and tyrosine phosphorylation differentially regulate rundown of synaptic versus extrasynaptic NMDAR-mediated current in rat hippocampal pyramidal neurons.

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