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. 2002 Aug;30(4):722-4.
doi: 10.1042/bst0300722.

Molecular evidence for the role of a ferric reductase in iron transport

A T McKie  1 , G O Latunde-Dada, S Miret, J A McGregor, G J Anderson, C D Vulpe, J M Wrigglesworth, R J Simpson
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Molecular evidence for the role of a ferric reductase in iron transport

A T McKie et al. Biochem Soc Trans. 2002 Aug.

Abstract

Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Dcytb is highly expressed in duodenal brush-border membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1). The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body.

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