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Clinical Trial
. 2002 Aug 27;59(4):560-2.
doi: 10.1212/wnl.59.4.560.

Transcranial magnetic stimulation for the treatment of seizures: a controlled study

W H Theodore  1 , K Hunter, R Chen, F Vega-Bermudez, B Boroojerdi, P Reeves-Tyer, K Werhahn, K R Kelley, L Cohen
Affiliations
Clinical Trial

Transcranial magnetic stimulation for the treatment of seizures: a controlled study

W H Theodore et al. Neurology. .

Abstract

Objective: To perform a controlled trial of transcranial magnetic stimulation (TMS).

Methods: Twenty-four patients with localization-related epilepsy were randomized to blinded active or placebo stimulation. Weekly seizure frequency was compared for 8 weeks before and after 1 week of 1-Hz TMS for 15 minutes twice daily.

Results: When the 8-week baseline and post-stimulation periods were compared, active patients had a mean seizure frequency reduction of 0.045 +/- 0.13 and sham-stimulated control subjects -0.004 +/- 0.20. Over 2 weeks, actively treated patients had a mean reduction in weekly seizure frequency of 0.16 +/- 0.18 and sham-stimulated control subjects 0.01 +/- 0.24. Neither difference was significant.

Conclusion: The effect of TMS on seizure frequency was mild and short lived.

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