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. 2002 Aug 27;59(4):627-9.
doi: 10.1212/wnl.59.4.627.

CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects

K Buerger  1 , S J Teipel, R Zinkowski, K Blennow, H Arai, R Engel, K Hofmann-Kiefer, C McCulloch, U Ptok, R Heun, N Andreasen, J DeBernardis, D Kerkman, H- J Moeller, P Davies, H Hampel
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CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects

K Buerger et al. Neurology. .

Erratum in

  • Neurology. 2004 Sep 28;63(6):1144

Abstract

In this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of tau protein phosphorylated at threonine 231 (p-tau(231)) in CSF correlate with progression of cognitive decline. High CSF p-tau(231) levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD. Independently, old age and APOE-epsilon 4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI.

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