Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Nov 15;277(46):44202-7.
doi: 10.1074/jbc.M207195200. Epub 2002 Aug 27.

A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast

Tilman Borggrefe  1 , Ralph Davis, Hediye Erdjument-Bromage, Paul Tempst, Roger D Kornberg
Affiliations
Free article

A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast

Tilman Borggrefe et al. J Biol Chem. .
Free article

Abstract

The Srb8, -9, -10, and -11 proteins of yeast have been isolated as a discrete, stoichiometric complex. The isolated complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II at serines 2 and 5. In addition to the previously reported human homologs of Srb10 and 11, we have identified TRAP230/ARC240 and TRAP240/ARC250 as the human homologs of Srb8 and Srb9, showing the entire Srb8/9/10/11 complex is conserved from yeast to humans.

PubMed Disclaimer

Publication types

MeSH terms