Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Oct;17(10):1056-63.
doi: 10.1046/j.1440-1746.2002.02780.x.

Cholangiocarcinoma: recent progress. Part 2: molecular pathology and treatment

Kunio Okuda  1 , Yasuni Nakanuma, Masaru Miyazaki
Affiliations
Review

Cholangiocarcinoma: recent progress. Part 2: molecular pathology and treatment

Kunio Okuda et al. J Gastroenterol Hepatol. 2002 Oct.

Abstract

Part 2 of this review discusses DNA damage in biliary epithelial cells in the development of cholangiocarcinoma, alterations in cell kinetics of biliary epithelial cells, biliary epithelial mitoinhibition, and apoptosis that includes the role of Bcl-2, transforming growth factor-beta, telomerase activities and deregulation of Ras and p53, cancer-associated antigens in cholangiocarcinoma, precancerous lesions, stroma formation and angiogenesis, cancer invasion, cell-cell and cell-matrix interactions, and the mechanism of evasion from immune surveillance. These discussions are followed briefly by treatments such as photodynamic therapy, and surgical approaches comparing resection and liver transplantation.

PubMed Disclaimer