Review
doi: 10.1016/s0092-8674(02)00904-2.
Competition and compensation: coupled to death in development and cancer
Affiliations
- PMID: 12202030
- DOI: 10.1016/s0092-8674(02)00904-2
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Review
Competition and compensation: coupled to death in development and cancer
Cell.
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Free article
Abstract
Developing systems exhibit robust and tolerant properties in the form of compensation and competition within cell groups. Fundamentally, these behaviors are governed by mechanisms that elicit proliferation and apoptosis. Recent insights from the Drosophila system implicate new determinants that specify "winners" and "losers" in this process.
Comment on
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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.Cell. 2002 Aug 23;110(4):467-78. doi: 10.1016/s0092-8674(02)00824-3. Cell. 2002. PMID: 12202036
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