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. 2002 Sep 15;35(6):760-2.
doi: 10.1086/342389. Epub 2002 Aug 23.

Effects of formulation and dosing strategy on amprenavir concentrations in the seminal plasma of human immunodeficiency virus type 1-infected men

Naumann I Chaudry  1 , Joseph J Eron, Odin J Naderer, Arlene S Pereira, M B Wire, Susan A Fiscus, Angela D M Kashuba
Affiliations

Effects of formulation and dosing strategy on amprenavir concentrations in the seminal plasma of human immunodeficiency virus type 1-infected men

Naumann I Chaudry et al. Clin Infect Dis. .

Abstract

We compared seminal plasma pharmacokinetic data for the investigational amprenavir prodrug GW433908 with those for amprenavir and an amprenavir-ritonavir combination regimen. All 3 regimens resulted in detectable blood plasma and seminal plasma concentrations of amprenavir. The majority of these concentrations were greater than the plasma protein-corrected 50% inhibitory concentration for wild-type human immunodeficiency virus type 1.

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