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. 2002 Sep;9(5):1129-31.
doi: 10.1128/cdli.9.5.1129-1131.2002.

CD4(+) CD25(+) T-cell production in healthy humans and in patients with thymic hypoplasia

Kathleen E Sullivan  1 , Donna McDonald-McGinn, Elaine H Zackai
Affiliations

CD4(+) CD25(+) T-cell production in healthy humans and in patients with thymic hypoplasia

Kathleen E Sullivan et al. Clin Diagn Lab Immunol. 2002 Sep.

Abstract

Regulatory T cells are found primarily in the CD4(+) CD25(+) fraction of T cells and play an important role in the prevention of autoimmunity. We examined CD4(+) CD25(+) T cells in 33 healthy children and adults and compared them to a population with an inherited form of thymic hypoplasia and a predisposition to autoimmune disease. Absolute numbers of CD4(+) CD25(+) T cells were markedly higher in healthy infants than in infants with chromosome 22q11.2 deletion syndrome.

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Figures

FIG. 1.
FIG. 1.
(Top) Fractions of CD4 CD25 T cells within the total lymphocyte gate; (bottom) absolute numbers of CD4 CD25 T cells. Gray diamonds represent patients with autoimmune disease. m, months.
See this image and copyright information in PMC

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