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Clinical Trial
. 2002;58(2):78-82.
doi: 10.1159/000064657.

Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania

M Simescu  1 , M Varciu, E Nicolaescu, D Gnat, J Podoba, M Mihaescu, F Delange
Affiliations
Clinical Trial

Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania

M Simescu et al. Horm Res. 2002.

Abstract

Objective: To evaluate the long-term efficacy and possible side effects of low doses of iodized oil on iodine nutrition and thyroid function in endemic goiter in Romania.

Methods: Random selection of 214 schoolchildren aged 6-14 years. Serial measurements of urinary iodine, thyroid volume with ultrasound, serum concentrations of thyrotropin, free thyroxine, thyroglobulin and thyroid autoantibodies before and up to 2 years after the oral administration of 200 mg iodine in iodized oil.

Results: Urinary iodine concentrations indicated a moderate iodine deficiency before therapy, sharply increased soon after therapy and slowly decreased thereafter but remained within the normal range up to more than 1 year after therapy. The prevalence of goiter was 29% before the administration of iodized oil and 9% 1 year later. Thyroid function tests and autoantibodies were normal before and up to 2 years after therapy.

Conclusion: A single dose of 200 mg iodine from oral Lipiodol appears adequate and safe for correcting moderate iodine deficiency in children.

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