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. 1975 Dec;32(6):660-6.
doi: 10.1038/bjc.1975.276.

Increase in type A virus particles induced in BALB/c mouse epidermis during chemical carcinogenesis

M C Bibby, G M Smith
Free PMC article

Increase in type A virus particles induced in BALB/c mouse epidermis during chemical carcinogenesis

M C Bibby et al. Br J Cancer. 1975 Dec.
Free PMC article

Abstract

Electron microscopic observations of normal BALB/c mouse epidermis revealed the presence of isolated intracisternal A particles. Hyperplasia, papilloma and carcinoma formation induced by topical application of the carcinogenic polycyclic hydrocarbons benz(a)pyrene (B(a)P) and 3-methylcholanthrene (MC) is accompanied by an increase in the mumber of A particles. Topical application of a non-carcinogenic irritant alpha-pinene (alpha P) failed to provide comparable changes. Examination of the nuclei indicated occasional electron dense granules in the nucleoplasm which became more common throughout the progression of carcinogenesis.

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