The nitration of proteins in platelets: significance in platelet function

Abstract

Exogenous peroxynitrite has been shown to inhibit or activate platelets according to the concentration added and, at the same time, nitrate platelet proteins. Here, recent evidence is discussed which indicates that nitration of proteins may also occur during normal platelet activation by collagen, by mechanical stimulation during isolation and by exposure to low levels of hydrogen peroxide. Furthermore, this nitration appears to be transient. The implications of these findings are discussed in terms of platelet biology and cell signaling processes.