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. 2002 Oct;76(19):10020-3.
doi: 10.1128/jvi.76.19.10020-10023.2002.

Lack of canonical E6 and E7 open reading frames in bird papillomaviruses: Fringilla coelebs papillomavirus and Psittacus erithacus timneh papillomavirus

Masanori Terai  1 , Rob DeSalle, Robert D Burk
Affiliations

Lack of canonical E6 and E7 open reading frames in bird papillomaviruses: Fringilla coelebs papillomavirus and Psittacus erithacus timneh papillomavirus

Masanori Terai et al. J Virol. 2002 Oct.

Abstract

Determination and analyses of the complete sequence of Fringilla coelebs papillomavirus and Psittacus erithacus timneh papillomavirus indicate that they represent a distinct and distant lineage of papillomaviruses. The lack of canonical E6-E7 open reading frames suggests that they serve adaptive functions during papillomavirus evolution.

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Figures

FIG. 1.
FIG. 1.
Location of predicted ORFs of FPV (A) and PePV (B). Each ORF is represented as a rectangle. Numbers show nucleotide positions of the start and stop codons and predicted molecular masses of proteins (kilodaltons).
FIG. 2.
FIG. 2.
Phylogenetic trees based on the alignment of the amino acid sequences (aa) of compiled ORFs (E1, E2, L1, and L2) of the indicated PV genomes (tree shown on the left) and based on aligned nucleotide sequences (nt) of just the L1 gene (shown on the right). The matrix used to generate the compiled ORF data tree had 2,862 aligned characters in it including gaps. Gaps were scored as missing in the parsimony analysis, and the resulting parsimony tree was 13,942 steps long with a confidence interval of 0.68 and a retention index (RI) of 0.38. The matrix used to generate the L1 nucleotide data tree had 2,088 aligned nucleotide characters in it including gaps. Gaps were scored as missing in the parsimony analysis, and the resulting parsimony tree was 7,401 steps long with a confidence interval of 0.39 and an RI of 0.32. Dots on the nodes in the trees indicate jackknife values for that node over 75%. The FPV and PePV sequences were compared with representative PV sequences (8). EqPV, equine PV; RPV, reindeer PV; HOPV, hamster oral PV; MnPV, Mastomys natalensis PV.
FIG. 3.
FIG. 3.
Alignment of the putative pRB-binding motif in the amino acid sequences of the FPV, PePV, BPV3, BPV4, BPV6, HPV1, and HPV16 E7 ORFs. The consensus motif is shaded. A cysteine-X-X-cysteine (Cys-X-X-Cys; C-X-X-C) motif and a leucine-X-cysteine-X-glutamine (Leu-X-Cys-X-Glu; L-X-C-X-E) motif are underlined.
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