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Review
. 2002 Sep;3(9):639-50.
doi: 10.1038/nrm908.

Seven-transmembrane receptors

Kristen L Pierce  1 , Richard T Premont, Robert J Lefkowitz
Affiliations
Review

Seven-transmembrane receptors

Kristen L Pierce et al. Nat Rev Mol Cell Biol. 2002 Sep.

Abstract

Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.

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