Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Sep;1(9):696-709.
doi: 10.1038/nrd895.

Protein tyrosine phosphatase 1B inhibitors for diabetes

Theodore O Johnson  1 , Jacques Ermolieff, Michael R Jirousek
Affiliations
Review

Protein tyrosine phosphatase 1B inhibitors for diabetes

Theodore O Johnson et al. Nat Rev Drug Discov. 2002 Sep.

Abstract

Increased incidence of type 2 diabetes mellitus and obesity has elevated the medical need for new agents to treat these disease states. Resistance to the hormones insulin and leptin are hallmarks of both type 2 diabetes and obesity. Drugs that can ameliorate this resistance should be effective in treating type 2 diabetes and possibly obesity. Protein tyrosine phosphatase 1B (PTP1B) is thought to function as a negative regulator of insulin and leptin signal transduction. This article reviews PTP1B as a novel target for type 2 diabetes, and looks at the challenges in developing small-molecule inhibitors of this phosphatase.

PubMed Disclaimer

MeSH terms

Substances

LinkOut - more resources