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Review
. 2002 Sep;2(9):705-13.
doi: 10.1038/nrc887.

How acute promyelocytic leukaemia revived arsenic

Jun Zhu  1 , Zhu Chen, Valérie Lallemand-Breitenbach, Hugues de Thé
Affiliations
Review

How acute promyelocytic leukaemia revived arsenic

Jun Zhu et al. Nat Rev Cancer. 2002 Sep.

Abstract

Despite its many therapeutic qualities, arsenic trioxide has been more commonly remembered as Madame Bovary's poison than as an anticancer drug. The ability of arsenic trioxide to treat acute promyelocytic leukaemia has radically changed this view, providing new insights into the pathogenesis of this malignancy and raising hopes that arsenicals might be useful in treating other cancers.

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