[The change of plasma level of endothelin-1 in patients with cor pulmonale and the effects of Captopril]

Abstract

The purpose of this study was to investigate the role of endothelin(ET) in the development of cor pulmonale and the mechanism of captopril in treatment. The plasma ET-1 levels of 36 patients with cor pulmonale and 20 normal subjects were measured by radioimmunoassay. Twenty patients were treated with antibiotics and oxygen, and the other 16 patients were treated with antibiotics, oxygen and captopril for 14 days. The results showed that the ET-1 level of patients with cor pulmonale (88.9 +/- 8.9 ng/L) was significantly higher than that of normal control (53.5 +/- 5.1 ng/L). After treatment, the ET-1 level declined significantly in both groups of patients (P < 0.01); the ET-1 level in patients treated with captopril was lower than that in patients not treated with captopril (P < 0.05), but the level of ET-1 in patients was still higher than that of normal control (P < 0.05). These suggest that ET-1 may play an important role in the onset of cor pulmonale and captopril can reduce the ET-1 level.