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Review
. 2002 Aug-Oct;19(1-2):213-7.
doi: 10.1007/s12031-002-0036-0.

Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease

Paul E Bendheim  1 , Burkhard Poeggeler, Eyal Neria, Vivi Ziv, Miguel A Pappolla, Daniel G Chain
Affiliations
Review

Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease

Paul E Bendheim et al. J Mol Neurosci. 2002 Aug-Oct.

Abstract

The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.

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