Review
doi: 10.1016/s0167-4781(02)00458-x.
Transcript elongation on a nucleoprotein template
Affiliations
- PMID: 12213658
- DOI: 10.1016/s0167-4781(02)00458-x
Item in Clipboard
Review
Transcript elongation on a nucleoprotein template
Biochim Biophys Acta.
.
Abstract
Chromatin forms a general, repeating barrier to elongation of transcripts by eukaryotic RNA polymerases. Recent studies of nucleosome structure and histone modifications reveal a set of likely mechanisms for control of elongation through chromatin. Genetic and biochemical studies of transcription have identified a set of accessory factors for transcript elongation by RNA polymerase II (Pol II) that appear to function in the context of chromatin. The C-terminal repeated domain (CTD) of Pol II may also play a role in regulating elongation through chromatin.
Similar articles
-
Efficient and rapid nucleosome traversal by RNA polymerase II depends on a combination of transcript elongation factors.J Biol Chem. 2011 Feb 25;286(8):6040-8. doi: 10.1074/jbc.M110.174722. Epub 2010 Dec 22. J Biol Chem. 2011. PMID: 21177855 Free PMC article.
-
Elongation by RNA polymerase II: structure-function relationship.Biochim Biophys Acta. 2002 Sep 13;1577(2):175-90. doi: 10.1016/s0167-4781(02)00451-7. Biochim Biophys Acta. 2002. PMID: 12213651 Review.
-
FACT, a factor that facilitates transcript elongation through nucleosomes.Cell. 1998 Jan 9;92(1):105-16. doi: 10.1016/s0092-8674(00)80903-4. Cell. 1998. PMID: 9489704
-
Evidence for eviction and rapid deposition of histones upon transcriptional elongation by RNA polymerase II.Mol Cell Biol. 2004 Dec;24(23):10111-7. doi: 10.1128/MCB.24.23.10111-10117.2004. Mol Cell Biol. 2004. PMID: 15542822 Free PMC article.
-
Chromatin Transcription Elongation - A Structural Perspective.J Mol Biol. 2025 Jan 1;437(1):168845. doi: 10.1016/j.jmb.2024.168845. Epub 2024 Oct 29. J Mol Biol. 2025. PMID: 39476950 Review.
Cited by
-
Recruitment of mRNA cleavage/polyadenylation machinery by the yeast chromatin protein Sin1p/Spt2p.Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9808-13. doi: 10.1073/pnas.0602014103. Epub 2006 Jun 20. Proc Natl Acad Sci U S A. 2006. PMID: 16788068 Free PMC article.
-
Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription.Genetics. 2010 Feb;184(2):321-34. doi: 10.1534/genetics.109.111526. Epub 2009 Nov 30. Genetics. 2010. PMID: 19948887 Free PMC article.
-
The Ras/PKA signaling pathway may control RNA polymerase II elongation via the Spt4p/Spt5p complex in Saccharomyces cerevisiae.Genetics. 2003 Nov;165(3):1059-70. doi: 10.1093/genetics/165.3.1059. Genetics. 2003. PMID: 14668364 Free PMC article.
-
The ESS1 prolyl isomerase and its suppressor BYE1 interact with RNA pol II to inhibit transcription elongation in Saccharomyces cerevisiae.Genetics. 2003 Dec;165(4):1687-702. doi: 10.1093/genetics/165.4.1687. Genetics. 2003. PMID: 14704159 Free PMC article.
-
The Paf1 complex promotes displacement of histones upon rapid induction of transcription by RNA polymerase II.BMC Mol Biol. 2008 Jan 14;9:4. doi: 10.1186/1471-2199-9-4. BMC Mol Biol. 2008. PMID: 18194564 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
