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Clinical Trial
. 2002 Sep;33(9):2334-5.
doi: 10.1161/01.str.0000027211.73567.fa.

Intracerebral hemorrhage triggers interleukin-6 and interleukin-10 release in blood

Tomasz Dziedzic  1 , Stanislaw Bartus, Aleksandra Klimkowicz, Maciej Motyl, Agnieszka Slowik, Andrzej Szczudlik
Affiliations
Clinical Trial

Intracerebral hemorrhage triggers interleukin-6 and interleukin-10 release in blood

Tomasz Dziedzic et al. Stroke. 2002 Sep.

Abstract

Background and purpose: Acute brain insult can cause systemic anti-inflammatory response, including anti-inflammatory cytokine release. The goal of this study was to determine the serum level of interleukin-6, interleukin-10, and interleukin-13 in patients with intracerebral hemorrhage and to correlate cytokine concentrations with stroke severity.

Methods: Thirty patients with intraparenchymal hemorrhage and 16 control subjects were included. Serum samples were collected on the second day of hemorrhagic stroke. Cytokine level was measured with the enzyme-linked immunosorbent assay method.

Results: Increased serum levels of interleukin-6 and interleukin-10 were detected in stroke patients. Interleukin-6 and interleukin-10 levels were significantly correlated with Glasgow Coma Scale score. In addition, interleukin-6 level correlated with blood volume and mass effect.

Conclusions: Intracerebral hemorrhage is associated with systemic release of anti-inflammatory cytokines.

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