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Comparative Study
. 2002 Sep;17(9):717-20.
doi: 10.1046/j.1525-1497.2002.10649.x.

Quantification of the Risk of Corticosteroid-induced Diabetes Mellitus Among the Elderly

David Blackburn  1 , Janet Hux, Muhammad Mamdani
Affiliations
Comparative Study

Quantification of the Risk of Corticosteroid-induced Diabetes Mellitus Among the Elderly

David Blackburn et al. J Gen Intern Med. 2002 Sep.

Abstract

We conducted a population-based cohort study using administrative databases to quantify the association between oral and inhaled corticosteroid use and onset of diabetes mellitus in the elderly. Proton pump inhibitor (PPI) users were used as a control group. Relative to PPI users (N = 53,845), oral corticosteroid users (N = 31,864) were more likely to develop diabetes (adjusted rate ratio [aRR], 2.31; 95% confidence interval [95% CI], 2.11 to 2.54); however, inhaled corticosteroid users (N = 38,441) were not (aRR, 1.03; 95% CI, 0.93 to 1.14). The estimated number needed to harm for continuous use of oral corticosteroids relative to PPIs over 1, 2, and 3 years of use were 41, 23, and 16, respectively.

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Figures

FIGURE 1
FIGURE 1
Incidence of diabetes over time among study groups.
See this image and copyright information in PMC

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