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. 2002 Sep;130(1-2):224-32.
doi: 10.1016/s0165-5728(02)00228-x.

Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence

Xiong-Biao Wang  1 , Maria Kakoulidou, Ricardo Giscombe, Qianhui Qiu, DeRen Huang, Ritva Pirskanen, Ann Kari Lefvert
Affiliations

Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence

Xiong-Biao Wang et al. J Neuroimmunol. 2002 Sep.

Abstract

Cytolytic T lymphocyte-associated antigen-4 (CTLA-4) plays a critical role in the down-regulation of antigen-activated immune responses. The aberrant CTLA-4 expression is characterized by low surface and intracellular levels of CTLA-4 protein, impaired up-regulation of CTLA-4 in T cells in response to ConA stimulation and high levels of soluble CTLA-4 (sCTLA-4) in serum. The serum levels of sCTLA-4 are positively correlated with the serum concentration of antibodies against the acetylcholine receptor. The (AT)(n) polymorphism in the 3'-untranslated region contributes to decreased mRNA stability and, hence, to reduced expression of CTLA-4.

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