Review
doi: 10.1152/ajplung.00154.2002.
Ventilator-induced lung injury: in vivo and in vitro mechanisms
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- PMID: 12225942
- DOI: 10.1152/ajplung.00154.2002
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Review
Ventilator-induced lung injury: in vivo and in vitro mechanisms
Am J Physiol Lung Cell Mol Physiol.
2002 Oct.
Free article
Abstract
A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.
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