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. 2002 Sep 19;4(19):3287-8.
doi: 10.1021/ol026555b.

Total syntheses of the marine pyrrole alkaloids polycitone A and B

Andreas T Kreipl  1 , Caroline Reid, Wolfgang Steglich
Affiliations

Total syntheses of the marine pyrrole alkaloids polycitone A and B

Andreas T Kreipl et al. Org Lett. .

Abstract

Polycitone B (2) was obtained in four steps from pyrrole dicarboxylic acid 3, including Friedel-Crafts reaction of the corresponding acid chloride with anisole. The conversion of 2 into polycitone A (1) was achieved in two steps via Mitsunobu alkylation of the pyrrolic NH group. The synthesis of polycitone A proceeds in 18% overall yield and offers the possibility of varying the substituents on the pyrrole ring.

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