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. 2002 Oct 1;35(7):880-2.
doi: 10.1086/342696. Epub 2002 Sep 11.

Human herpesvirus 8-positive Castleman disease in human immunodeficiency virus-infected patients: the impact of highly active antiretroviral therapy

Laurent Aaron  1 , Olivier Lidove, Cherine Yousry, Laurent Roudiere, Bertrand Dupont, Jean Paul Viard
Affiliations

Human herpesvirus 8-positive Castleman disease in human immunodeficiency virus-infected patients: the impact of highly active antiretroviral therapy

Laurent Aaron et al. Clin Infect Dis. .

Abstract

We report the case histories of 7 human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) who had a diagnosis of Castleman disease. All 6 patients who were treated responded to chemotherapy; immune reconstitution was observed in 5 patients, but it did not prevent relapse of Castleman disease. However, the mean duration of survival observed in this series (48 months) was most probably due to immune reconstitution resulting from receipt of HAART, which reduced the mortality associated with HIV disease.

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