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. 2002 Aug;4(4):693-6.
doi: 10.1089/15230860260220201.

Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span

Akira Mitsui  1 , Junji Hamuro, Hajime Nakamura, Norihiko Kondo, Yoko Hirabayashi, Sonoko Ishizaki-Koizumi, Tadashi Hirakawa, Tohru Inoue, Junji Yodoi
Affiliations

Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span

Akira Mitsui et al. Antioxid Redox Signal. 2002 Aug.

Abstract

Transgenic (Tg) mice overexpressing human thioredoxin (TRX), a small redox-active protein, were produced to investigate the role of the protein in a variety of stresses. Bone marrow cells from TRX-Tg mice were more resistant to ultraviolet C-induced cytocide compared with those from wild type (WT) C57BL/6 mice. TRX-Tg mice exhibited extended median and maximum life spans compared with WT mice. Telomerase activity in spleen tissues in TRX-Tg mice was higher than that in WT mice. These results suggest that overexpression of TRX results in resistance against oxidative stress and a possible extension of life span without apparent abnormality in mammals.

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