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Review
. 2002 Oct;14(5):633-9.
doi: 10.1016/s0955-0674(02)00364-2.

Cell interactions with three-dimensional matrices

Edna Cukierman  1 , Roumen Pankov, Kenneth M Yamada
Affiliations
Review

Cell interactions with three-dimensional matrices

Edna Cukierman et al. Curr Opin Cell Biol. 2002 Oct.

Abstract

Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments. These three-dimensional systems are illuminating mechanisms of cell-matrix interactions in living organisms.

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