Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2002 Oct;46(10):3283-5.
doi: 10.1128/AAC.46.10.3283-3285.2002.

Comparison of in vitro activities of gatifloxacin and ciprofloxacin against four taxa of rapidly growing mycobacteria

Barbara A Brown-Elliott  1 , Richard J Wallace Jr, Christopher J Crist, Linda Mann, Rebecca W Wilson
Affiliations
Comparative Study

Comparison of in vitro activities of gatifloxacin and ciprofloxacin against four taxa of rapidly growing mycobacteria

Barbara A Brown-Elliott et al. Antimicrob Agents Chemother. 2002 Oct.

Abstract

By using current NCCLS broth microdilution methods, we found that gatifloxacin inhibited 90% of the isolates of the Mycobacterium fortuitum group at < or =0.12 micro g/ml and 90% of the Mycobacterium chelonae isolates at < or =4 micro g/ml. Gatifloxacin was generally fourfold more active than ciprofloxacin. We recommend that both gatifloxacin and ciprofloxacin be tested routinely against rapidly growing mycobacteria.

PubMed Disclaimer

References

    1. Bauernfiend, A. 1997. Comparison of the antibacterial activities of the quinolones Bay 12-039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin. J. Antimicrob. Chemother. 40:639-651. - PubMed
    1. Brown, B. A., B. Springer, V. A. Steingrube, R. W. Wilson, G. E. Pfyffer, M. J. Garcia, M. C. Menendez, B. Rodriguez-Salgado, K. C. Jost, S. H. Chiu, G. O. Onyi, E. C. Böttger, and R. J. Wallace, Jr. 1999. Description of Mycobacterium wolinskyi and Mycobacterium goodii, two new rapidly growing species related to Mycobacterium smegmatis and associated with human wound infections: a cooperative study from the International Working Group on Mycobacterial Taxonomy. Int. J. Syst. Bacteriol. 49:1493-1511. - PubMed
    1. Brown, B. A., R. J. Wallace, Jr., G. O. Onyi, V. De Rosas, and R. J. Wallace III. 1992. Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum, Mycobacterium chelonae, and M. chelonae-like organisms. Antimicrob. Agents Chemother. 36:180-184. - PMC - PubMed
    1. Brown-Elliott, B. A., R. J. Wallace, Jr., R. Blinkhorn, C. J. Crist, and L. M. Mann. 2001. Successful treatment of disseminated Mycobacterium chelonae infection with linezolid. Clin. Infect. Dis. 33:1433-1434. - PubMed
    1. Jones, R. N., M. A. Pfaller, and The SENTRY Antimicrobial Surveillance Program Participants Group. 2001. Can antimicrobial susceptibility testing results for ciprofloxacin or levofloxacin predict susceptibility to a newer fluoroquinolone, gatifloxacin?: report from the SENTRY Antimicrobial Surveillance Program (1997-1999). Diagn. Microbiol. Infect. Dis. 39:237-243. - PubMed

Publication types

MeSH terms

LinkOut - more resources