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. 2002 Oct;46(10):3323-6.
doi: 10.1128/AAC.46.10.3323-3326.2002.

In vitro synergistic interaction between amphotericin B and pentamidine against Scedosporium prolificans

Javier Afeltra  1 , Eric Dannaoui, Jacques F G M Meis, Juan L Rodriguez-Tudela, Paul E Verweij
Affiliations

In vitro synergistic interaction between amphotericin B and pentamidine against Scedosporium prolificans

Javier Afeltra et al. Antimicrob Agents Chemother. 2002 Oct.

Abstract

To develop new approaches for the treatment of invasive infections caused by Scedosporium prolificans, the in vitro interaction between amphotericin B and pentamidine against 30 clinical isolates was evaluated using a checkerboard microdilution method based on the National Committee for Clinical Laboratory Standards M38-P guidelines. The interaction between the drugs was analyzed using fractional inhibitory concentration index (FICI) analysis and response surface modeling. Amphotericin B alone was inactive against all the isolates. The geometric mean MIC for pentamidine was 57 micro g/ml (range, 8 to 256 micro g/ml; MIC at which 50% of the isolates tested were inhibited [MIC(50)], 64 micro g/ml; MIC(90), 128 micro g/ml). The combination was synergistic against 28 of 30 isolates (93.3%) by FICI analysis and 30 of 30 (100%) by response surface modeling analysis. Antagonism was not observed.

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