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Review
. 2002 Sep;110(6):725-30.
doi: 10.1172/JCI16388.

Do oxysterols control cholesterol homeostasis?

Ingemar Björkhem  1
Affiliations
Review

Do oxysterols control cholesterol homeostasis?

Ingemar Björkhem. J Clin Invest. 2002 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Primary cholesterol oxygenation reactions mediated by different cytochrome P-450 species or occurring nonenzymatically in the presence of reactive oxygen species (ROS) (43). The oxygenation of cholesterol into 25-hydroxycholesterol is catalyzed by cholesterol 25-hydroxylase, a non-heme iron protein (7). The quantitatively most important oxysterols present in human circulation are underlined.
Figure 2
Figure 2
Roles of CYP27 and CYP46 in transport of cholesterol from extrahepatic organs to the liver. Cholesterol does not pass readily across the blood-brain barrier, but cholesterol produced in the brain can be oxidized by CYP46 to form the more soluble species 24S-hydroxycholesterol. Likewise, 27-hydroxycholesterol is formed in other extrahepatic cells and contributes to the net flow of circulating oxysterols from other organs to the liver (10).
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References

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