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. 2001 Oct 21:(20):2084-5.

A new practical ketone synthesis directly from carboxylic acids: first application of coupling reagents in palladium catalysis

L J Goossen  1 , K Ghosh
Affiliations
  • PMID: 12240174

A new practical ketone synthesis directly from carboxylic acids: first application of coupling reagents in palladium catalysis

L J Goossen et al. Chem Commun (Camb). .

Abstract

A new palladium-catalyzed cross-coupling reaction between arylboronic acids and carboxylic acids, activated in situ for the oxidative addition to a tricyclohexylphosphine palladium(0) catalyst by treatment with di(N-succinimidyl) carbonate (DSC) is disclosed, which allows the high-yielding synthesis of various functionalized arylketones under mild conditions.

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