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. 2001 Sep 21:(18):1760-1.
doi: 10.1039/b106090m.

Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction

S A Saldanha  1 , L M Birch, M E Webb, B K Nabbs, F von Delft, A G Smith, C Abell
Affiliations

Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction

S A Saldanha et al. Chem Commun (Camb). .

Abstract

The decarboxylation of L-aspartate by E. coli L-aspartate-alpha-decarboxylase (ADC) is shown to occur with retention of configuration; analysis of the protein structure identifies Tyr58 as the proton donor in the decarboxylation mechanism.

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