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. 2002 Jul-Aug;57(7-8):717-20.
doi: 10.1515/znc-2002-7-828.

Aurones interfere with Leishmania major mitochondrial fumarate reductase

Oliver Kayser  1 , Ming Chen, Arsalan Kharazmi, Albrecht F Kiderlen
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Free article

Aurones interfere with Leishmania major mitochondrial fumarate reductase

Oliver Kayser et al. Z Naturforsch C J Biosci. 2002 Jul-Aug.
Free article

Abstract

A series of aurones was analyzed for the ability to inhibit respiratory functions of mitochondria of Leishmania parasites. The aim of this study was to find a rational explanation for the activity of certain aurones and auronols as novel antiprotozoal compounds of plant origin. In a cell-free assay mitochondrial fumarate reductase from L. donovani was inhibited in a concentration-dependent manner. The most active compounds were 4',6-dihydroxyaurone and 6-methoxyaurone which inhibited parasite enzyme activity at 25 nM by over ninety percent.

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