Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Sep 20;297(5589):2053-6.
doi: 10.1126/science.1076311.

Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA

Cesar Llave  1 , Zhixin Xie, Kristin D Kasschau, James C Carrington
Affiliations

Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA

Cesar Llave et al. Science. .

Abstract

Micro-RNAs (miRNAs) are regulatory molecules that mediate effects by interacting with messenger RNA (mRNA) targets. Here we show that Arabidopsis thaliana miRNA 39 (also known as miR171), a 21-ribonucleotide species that accumulates predominantly in inflorescence tissues, is produced from an intergenic region in chromosome III and functionally interacts with mRNA targets encoding several members of the Scarecrow-like (SCL) family of putative transcription factors. miRNA 39 is complementary to an internal region of three SCL mRNAs. The interaction results in specific cleavage of target mRNA within the region of complementarity, indicating that this class of miRNA functions like small interfering RNA associated with RNA silencing to guide sequence-specific cleavage in a developmentally controlled manner.

PubMed Disclaimer

Comment in

  • DNA events. An RNA microcosm.
    Baulcombe D. Baulcombe D. Science. 2002 Sep 20;297(5589):2002-3. doi: 10.1126/science.1077906. Science. 2002. PMID: 12242426 No abstract available.

Publication types

MeSH terms