Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Sep;43(3):444-9.
doi: 10.1016/s0028-3908(02)00115-6.

Modulation of voltage-gated K(+) channels Kv11 and Kv1 4 by forskolin

K Matthias  1 , G Seifert, S Reinhardt, C Steinhäuser
Affiliations

Modulation of voltage-gated K(+) channels Kv11 and Kv1 4 by forskolin

K Matthias et al. Neuropharmacology. 2002 Sep.

Abstract

Forskolin (FSK) affects voltage-gated K(+) (Kv) currents in different cell types, but it is not known which of the various subunits form FSK-sensitive Kv channels. We compared the effect of the compound at Kv1.1 and Kv1.4 channels ectopically expressed in HEK 293 cells. Low FSK concentrations induced a phosphorylation-dependent potentiation of Kv1.1 currents. At higher concentrations, this effect was superimposed by a fast, cAMP-independent channel block. Kv1.4 currents were inhibited with lower potency by FSK but were not modified by phosphorylation. The variable effect of the compound might help to distinguish between Kv subunits expressed by native cells.

PubMed Disclaimer

Publication types

LinkOut - more resources