[The action of insulin on ribonucleic acid metabolism (author's transl)]

Abstract

The incorporation of 3H-uridine into liver ribosomes is reduced in alloxan-diabetic rats. This reduction affects mRNA as well as rRNA. Insulin-substitution therapy of diabetic animals restores to normal the incorporation rates of uridine into both mRNA and rRNA. There is a manifest connection between the known reduction of polyribosomes in diabetes mellitus and reduced synthesis of mRNA; moreover, a connection to the reduced production of rRNA seems also to be possible.