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. 1961 May 6;176(5):427-31.

In vitro assessment of commercial contraceptive jellies and creams

J Macleod, A J Sobrero, W Inglis
  • PMID: 12254949

In vitro assessment of commercial contraceptive jellies and creams

J Macleod et al. JAMA. .

Abstract

PIP: The sperm-immobilizing capacity of 54 commercial contraceptive jellies and creams was evaluated by 3 laboratory technics: 1) a modified Brown-Gamble dilution test, 2) a modified Sander-Cramer dilution test, and 3) a Mende-Berliner titration test. Observations of sperm mobility were made within 20 seconds after the contraceptive preparation was mixed with good quality human semen. The median of the 3 results was taken as the measure of the effectiveness of the preparation. The wide range of median results indicated considerable disparity in the effectiveness of the preparations. The ranking of the effectiveness of the preparations as determined by the 3 techniques were in fairly good agreement, as measured by the Spearman rank-order correlation coefficient. Thus, the reliability of the technics was felt to be satisfactory. However a determination of the validity of the 3 techniques which would involve correlation between laboratory values and clinical measures of effectiveness, was not possible at the time.

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