[Blood sugar level and immunoreactive insulin in the blood plasma in pregnant women with supposed prediabetes in the dynamics of a normal glucose tolerance test]

Abstract

A study was made of the blood sugar level and blood plasma immunoreactive insulin (IRI) on fasting stomach and in the GTT dynamics in 33 pregnant women with a possible prediabetes and also in 8 nonpregnant women and 20 pregnant women of the control group. GTT proved to be normal in all the women under study. There proved to be no significant difference between the blood sugar level on fasting stomach and in the GTT dynamics in pregnant women of both groups and in the nonpregnant women. In comparison with nonpregnant women, pregnant women of both groups displayed a higher mean blood sugar elevation during the whole GTT period--in the II and III trimesters. Blood plasma IRI in the pregnant women with a possible prediabetes and in the pregnant women of the control group on fasting stomach and in the GTT dynamics showed no significant difference between one another. In comparison with nonpregnant women, pregnant women of both groups showed an increase in IRI content of fasting stomach and in the GTT dynamics beginning from the II trimester and reaching the maximal level during the III trimester of pregnancy. IRI over glucose index did not differ in pregnant women of both groups from the nonpregnant women. Thus it was revealed that hyperinsulinemia in pregnancy in practically healthy women and in women with a possible prediabetes was compensatory in character.