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Case Reports
. 1982 Jun;10(6):389-93.

[Effects of an anti-progestin steroid in women: interruption of the menstrual cycle or early pregnancy (author's transl)]

[Article in French]
W Herrman, R Wyss, A Riondel, D Philibert, G Teutsch, E Sakiz, E E Baulieu
  • PMID: 12264222
Case Reports

[Effects of an anti-progestin steroid in women: interruption of the menstrual cycle or early pregnancy (author's transl)]

[Article in French]
W Herrman et al. Contracept Fertil Sex (Paris). 1982 Jun.

Abstract

PIP: The 19-nor steroid, RU-486, has an affinity for progestin receptors, and is also a progesterone as shown in animal studies. RU-486 was administered orally in a dose of 200 mg a day for 4 consecutive days to 11 women aged 18-34 seeking 1st trimester abortion. Bleeding occurred, in most cases, on the 1st day, followed by expulsion on the 3rd day in 2 cases, on the 4th day in 3 cases, on the 5th day in 3 cases, and on the 8th day in 1 case. 2 patients failed to abort. There were no complications, and only 1 patient required blood transfusion. Normal ovarian activity resumed in all cases. RU-486 can also be used to induce menstruation when administered in a dose of 50 mg a day for 4 days beginning on the 22nd day of a normal cycle. The use of RU-486 as an abortifacient agent seems to be more effective than the use of massive doses of estrogen or of prostaglandins, and to be certainly less traumatic than curettage or vacuum aspiration. Contraindications to its use and potential side effects, especially hepatic, have still to be established.

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