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. 2002 Oct 21;12(20):2919-23.
doi: 10.1016/s0960-894x(02)00622-4.

Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC)

Michael L Curtin  1 , Robert B Garland, H Robin Heyman, Robin R Frey, Michael R Michaelides, Junling Li, Lori J Pease, Keith B Glaser, Patrick A Marcotte, Steven K Davidsen
Affiliations

Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC)

Michael L Curtin et al. Bioorg Med Chem Lett. .

Abstract

A series of succinimide hydroxamic acids was prepared and evaluated in vitro for HDAC inhibition and tumor cell antiproliferation. While the original macrocyclic analogue 6 was quite potent in both assays, several appropriately substituted non-macrocyclic succinimides, such as 23, were equipotent.

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