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Review
. 2002 Oct;184(20):5529-32.
doi: 10.1128/JB.184.20.5529-5532.2002.

Growing repertoire of AraC/XylS activators

Susan M Egan  1
Affiliations
Review

Growing repertoire of AraC/XylS activators

Susan M Egan. J Bacteriol. 2002 Oct.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Mechanisms used by AraC/XylS family regulators of virulence factor expression. (A) In the absence of ToxT activation, the nucleoid protein H-NS represses tcpA and ctxA expression in V. cholerae, most likely by binding to a long stretch of DNA in the vicinity of the promoters. ToxT binding to these promoter regions presumably displaces H-NS and allows a direct interaction with the RNAP α-CTD. Each ToxT monomer is illustrated with two domains. (B) Activation by Rns of its own promoter in enterotoxigenic E. coli requires binding to sites at +83.5 as well as at −224.5. The size of the sites suggests the binding of a single Rns monomer to each and the possibility that a dimer of Rns simultaneously contacts each of these sites to form a DNA loop. How Rns binding to these two sites activates transcription remains to be determined. Each Rns monomer is illustrated with two domains. (C) Transcription activation by InvF in S. enterica serovar Typhimurium requires the chaperone protein SicA, although InvF can bind to the promoter DNAs in vitro in the absence of SicA. The InvF monomer is illustrated with two domains.
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Comment on

References

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