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Clinical Trial
. 2002 Sep:43:s91-7.
doi: 10.1192/bjp.181.43.s91.

Randomised controlled trial of cognitive-behavioural therapy in early schizophrenia: acute-phase outcomes

S Lewis  1 , N Tarrier, G Haddock, R Bentall, P Kinderman, D Kingdon, R Siddle, R Drake, J Everitt, K Leadley, A Benn, K Grazebrook, C Haley, S Akhtar, L Davies, S Palmer, B Faragher, G Dunn
Affiliations
Clinical Trial

Randomised controlled trial of cognitive-behavioural therapy in early schizophrenia: acute-phase outcomes

S Lewis et al. Br J Psychiatry Suppl. 2002 Sep.

Abstract

Background: Cognitive-behavioural therapy (CBT) improves persistent psychotic symptoms.

Aims: To test the effectiveness of added CBT in accelerating remission from acute psychotic symptoms in early schizophrenia.

Method: A 5-week CBT programme plus routine care was compared with supportive counselling plus routine care and routine care alone in a multi-centre trial randomising 315 people with DSM-IV schizophrenia and related disorders in their first (83%) or second acute admission. Outcome assessments were blinded.

Results: Linear regression over 70 days showed predicted trends towards faster improvement in the CBT group. Uncorrected univariate comparisons showed significant benefits at 4 but not 6 weeks for CBT v. routine care alone on Positive and Negative Syndrome Scale total and positive sub-scale scores and delusion score and benefits v. supportive counselling for auditory hallucinations score.

Conclusions: CBT shows transient advantages over routine care alone or supportive counselling in speeding remission from acute symptoms in early schizophrenia.

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